Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis
نویسندگان
چکیده
منابع مشابه
Intensified Antituberculosis Therapy in Adults with Tuberculous Meningitis.
BACKGROUND Tuberculous meningitis is often lethal. Early antituberculosis treatment and adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients with the condition still die. We hypothesized that intensified antituberculosis treatment would enhance the killing of intracerebral Mycobacterium tuberculosis organisms and decrease the rate of death among patients....
متن کاملClinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen
Background Drug-resistant tuberculous meningitis (TBM) is difficult to diagnose and treat. Mortality is high and optimal treatment is unknown. We compared clinical outcomes of drug-resistant and -susceptible TBM treated with either standard or intensified antituberculosis treatment. Methods We analyzed the influence of Mycobacterium tuberculosis drug resistance on the outcomes of patients wit...
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© 2014 Lippincott Williams & Wilkins www.pidj.com | 993 In Reply: Short Intensified Treatment in Children With Drug-Susceptible Tuberculous Meningitis child effectively on isoniazid monotherapy for most of their treatment. This can be a problem in areas with high prevalence of isoniazid resistance. In addition, the poor CSF penetration of ethambutol renders its inclusion in the regimen question...
متن کاملHydrocephalus and tuberculous meningitis in adults.
Hydrocephalus is well recognised as a complication of tuberculous meningitis in childhood. This complication may occur more frequently in the acute stage in adults than has been appreciated. Three cases are described to illustrate this observation. Early recognition and prompt treatment may improve mortality and morbidity at any age.
متن کاملTuberculous meningitis in South African urban adults.
We retrospectively reviewed 56 adults with culture-proven tuberculous meningitis (TBM), investigating clinical signs, cerebrospinal fluid (CSF) findings and outcome. There were 50 patients, aged 18-59 years, 39 with and 11 without human immunodeficiency virus (HIV) infection. Six were aged 60 years or older. Neurological signs of TBM in 18-59-year-olds were unaffected by HIV serostatus while, c...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2016
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1507062